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KMID : 1123920080220061537
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 6 p.1537 ~ p.1543
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Effect of Prior Gastrodia elata Blume diet on Diabetic Mellitus Induced Rats at Antioxidant Effect and Pathophysiology factor
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Sim Ki-Cheol
Kim Eun-Jung
Jeong Hyun-Woo
Kim Gi-Do
Kim Kyung-Yoon
Kim Gye-Yeop
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Abstract
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The purpose of this study was investigation to examine the prevention diabetic mellitus and treatment effect on Gastrodia Elata Blume(GEB) dieted at prior and after induced diabetic application. Prior induced diabetic 3 weeks ago application GEB dieted. It is to analysis changes in body weight, blood glucose, SOD, CAT and histopathological findings. For the fingding significantly concentration diabetic rats were divided into 3 different experimental groups and each groups were induced diabetic. Experimental group Ⅰ (STZ-induced diabetic rats; n=10), experimental group Ⅱ (after induced DM and GEB dieted rats; n=10), experimental group Ⅲ (Prior GEB dieted thereafter DM induced; n=10). Prior and After GEB dieted application was that body weight, blood glucose were increase in experimental group Ⅱ, Ⅲ. Specially, group Ⅲ was significantly change than group Ⅱ at 1st weeks. and the level of CAT were significantly decrease in experimental group Ⅱ, Ⅲ than group Ⅰ. but SOD level was increase in experimental group Ⅱ, Ⅲ than group Ⅰ. In histological observation; group Ⅰ showed decrease in the intensity and incidence of vacuolations, cellular infiltration and hypertrophy of in liver and kidney. The Gomori’s stain result, group Ⅰ showed disruption -cell in pancrease.
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KEYWORD
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prior Gastrodia elata blume diet, diabetes rat, antioxidant
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